2,4-Dichloropyrimidine-5-carbaldehyde → 1-(2,4-Dichloropyrimidin-5-yl)ethan-1-ol
反応式
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([CH:9]=[O:10])=[CH:4][N:3]=1.[CH3:11][Mg]Br>C1COCC1>[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([CH:9]([OH:10])[CH3:11])=[CH:4][N:3]=1参加物
4
反応条件
- 温度
- -78 °C
実験手順
To a stirred solution of 2,4-dichloro-pyrimidine-5-carbaldehyde (Example 17, 1.01 g, 5.7 mmol) in THF (10 mL), methyl magnesium bromide (Aldrich, 3 M in ether, 6.27 mmol, 2.1 mL) was added slowly at −78° C. The mixture was stirred for an additional 2 hours at −78° C. and the reaction was quenched with 1N HCl (10 mL). The resulting mixture was extracted with EtOAc and the extract was dried with sodium sulfate. Removal of solvent gave a brown solid. 1.07 g, 97%. MS (M+H)+, 193.
後処理
- customthe reaction was quenched with 1N HCl (10 mL)
- extractionThe resulting mixture was extracted with EtOAc
- dry with materialthe extract was dried with sodium sulfate
- customRemoval of solvent
- customgave a brown solid
出典と根拠
- ORDレコード
- ord-f0dabc8583a943b48fa5f0303b1eebc3
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07405220B2
反応ノート
読み込み中…