Oxalyl chloride → 7-Chlorocarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furane-6-yl Methacrylate

HRID 75084ノート

反応式

HRID 75084 の反応式
[C:1]([O:6][CH:7]1[CH:11]2[O:12][C:13](=[O:19])[CH:14]3[CH:15]([C:16](O)=[O:17])[CH:8]1[CH2:9][CH:10]23)(=[O:5])[C:2]([CH3:4])=[CH2:3].C(Cl)(=O)C([Cl:23])=O>C1(C)C=CC=CC=1>[C:1]([O:6][CH:7]1[CH:11]2[O:12][C:13](=[O:19])[CH:14]3[CH:15]([C:16]([Cl:23])=[O:17])[CH:8]1[CH2:9][CH:10]23)(=[O:5])[C:2]([CH3:4])=[CH2:3]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 206800246-Methacryloyloxy-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furane-7-carboxylic Acid

生成物 1

HCID 866409437-Chlorocarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furane-6-yl Methacrylate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Suspended into 135 mL of toluene was 18.0 g of the carboxylic acid (26) obtained in Synthesis Example 1-1-2, and then into the resulting suspension was gradually added 10.3 g of oxalyl chloride at 80° C. After this mixture was stirred for 4 hours, toluene was removed by distillation under reduced pressure to obtain the intended product. The obtained acid chloride was used in the next reaction without further purification.

後処理

  1. customobtained in Synthesis Example 1-1-2
  2. customat 80° C
  3. customtoluene was removed by distillation under reduced pressure
  4. customto obtain the intended product

出典と根拠

ORDレコード
ord-fe22ae6ffcae43baacdaa4e45626e590
出典データセット
uspto-grants-2014_09
特許番号
US08835097B2

反応ノート

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