Sodium hydride → HCID 66886384、化合物

HRID 750886

反応式

HRID 750886 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[C:11]([CH3:13])[NH:10][N:9]=2)=[CH:4][CH:3]=1.[C:14]([O:18][C:19](=[O:27])[NH:20][C:21]([CH3:26])([CH3:25])[CH2:22][CH2:23]Cl)([CH3:17])([CH3:16])[CH3:15].[H-].[Na+]>CN1C(=O)N(C)CCC1.[I-].C([N+](CCCC)(CCCC)CCCC)CCC>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]=[C:11]([CH3:13])[N:10]([CH2:23][CH2:22][C:21]([NH:20][C:19](=[O:27])[O:18][C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:26])[CH3:25])[N:9]=2)=[CH:6][CH:7]=1

参加物

6

反応物 3

HCID 24758Sodium hydrideHCID 431667563-(4-Fluoro-phenyl)-5-methyl-[1,2,4]triazoleHCID 57429079tert-butyl N-(4-chloro-2-methylbutan-2-yl)carbamate

生成物 1

HCID 66886384HCID 66886384、化合物

試薬・触媒・溶媒 2

HCID 67553Tetrabutylammonium Iodide触媒HCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-溶媒

実験手順

5.88 g (33 mmol) 3-(4-fluoro-phenyl)-5-methyl-[1,2,4]triazole are dissolved in 40 mL DMPU and reacted with 11.04 g (50 mmol) tert-butyl(3-chloro-1,1-dimethyl-propyl)-carbamate, 1.59 g (40 mmol, 60%) sodium hydride and 2.21 g (6 mmol) tetrabutylammonium iodide as described for intermediate product 1c).

出典と根拠

ORDレコード
ord-43acf2c4c99b4d0cb767577bf511beac
出典データセット
uspto-grants-2008_07
特許番号
US07405232B2

関連ノート

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