1-(4-(Benzyloxy)phenyl)-2-((1-adamantylmethyl)amino)ethanol → HCID 59437178、化合物
反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([OH:29])[CH2:16][NH:17][CH2:18][C:19]23[CH2:28][CH:23]4[CH2:24][CH:25]([CH2:27][CH:21]([CH2:22]4)[CH2:20]2)[CH2:26]3)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[C:19]12([CH2:18][NH:17][CH2:16][CH:15]([C:12]3[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=3)[OH:29])[CH2:28][CH:23]3[CH2:22][CH:21]([CH2:27][CH:25]([CH2:24]3)[CH2:26]1)[CH2:20]2参加物
4
実験手順
To a solution of 1-(4-(benzyloxy)phenyl)-2-((1-adamantylmethyl)amino)ethanol (0.8 g, 2.05 mmol) in MeOH (10 mL) was added Pd(OH)2 (80 mg). The mixture was stirred at rt under H2 for 30 min. The mixture was filtered and concentrated to give 4-(2-((1-adamantylmethyl)amino)-1-hydroxyethyl)phenol (0.5 g, yield: 81%). 1H NMR: (CDCl3, 400 MHz) δ=1.53 (m, 6H), 1.65 (m, 6H), 1.97 (m, 3H), 2.26 & 2.36 (dd, 2H), 2.62&2.83 (dd, 2H), 4.60 (m, 1H), 6.78 (m, 2H), 7.22 (m, 2H).