Acetaldehyde → HCID 178419035、化合物

HRID 7515

反応式

HRID 7515 の反応式
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:16][C:17]([N+:24]#[C-:25])([CH3:23])[CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20].[CH:26](=[O:28])[CH3:27].[C:29]([Cl:32])(=O)[CH3:30]>Cl(O)(=O)(=O)=O>[Cl-:32].[C:26]([N+:1]1[C:29]([CH3:30])=[C:25]([NH:24][C:17]([CH3:23])([CH3:16])[CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])[N:3]2[CH:4]=[CH:5][CH:6]=[C:7]([O:8][CH2:9][C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:2]=12)(=[O:28])[CH3:27]

参加物

6

反応物 4

HCID 177AcetaldehydeHCID 6367Acetyl chlorideHCID 267251,1,3,3-Tetramethylbutyl isocyanideHCID 903342-Amino-3-benzyloxypyridine

生成物 1

HCID 178419035HCID 178419035、化合物

試薬・触媒・溶媒 1

HCID 24247Perchloric Acid溶媒

実験手順

Example 9 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-3-benzyloxypyridine (0.1 M, DCM), 0.575 ml (0.115 mmol) 1,1,3,3-tetramethylbutylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) acetaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

出典と根拠

ORDレコード
ord-35de8171a48847fc924677310cf7789a
出典データセット
uspto-grants-2006_08
特許番号
US07087607B2

関連ノート

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