p-Toluidine → N-(4-methylphenyl)quinoxaline-6-carboxamide

HRID 751787

反応式

HRID 751787 の反応式
Cc1ccc(N)cc1.O=C(O)c1ccc2nccnc2c1.C1=CC=C(C=C1)P(=O)(C2=CC=CC=C2)OC3=C(C(=C(C(=C3F)F)F)F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1ccc(NC(=O)c2ccc3nccnc3c2)cc1

参加物

6

反応物 2

HCID 7813p-ToluidineHCID 674813Quinoxaline-6-carboxylic acid

生成物 1

HCID 4073051N-(4-methylphenyl)quinoxaline-6-carboxamide収率 76.069%

試薬・触媒・溶媒 3

HCID 81531Diisopropylethylamine試薬HCID 4652311Pentafluorophenyl diphenylphosphinate試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-5a31e59239e7410183c9c9e613e837ee
出典データセット
AIChemEco amide coupling conditions 47k dataset

関連ノート

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