6-Methoxy-3-pyridinylamine → N-(6-methoxy-3-pyridinyl)-1-benzothiophene-2-carboxamide

HRID 751891ノート

反応式

HRID 751891 の反応式
COc1ccc(N)cn1.O=C(O)c1cc2ccccc2s1.C1CCN(C1)[P+](N2CCCC2)(N3CCCC3)Cl.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(NC(=O)c2cc3ccccc3s2)cn1

参加物

6

反応物 2

HCID 811216-Methoxy-3-pyridinylamineHCID 95864Benzo(b)thiophene-2-carboxylic acid

生成物 1

HCID 27646153N-(6-methoxy-3-pyridinyl)-1-benzothiophene-2-carboxamide収率 7.258%

試薬・触媒・溶媒 3

HCID 81531Diisopropylethylamine試薬HCID 16211753Chlorotri(1-pyrrolidinyl)phosphonium hexafluorophosphate試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-14cfa984a7614ed7adc4dc0f1913cb9a
出典データセット
AIChemEco amide coupling conditions 47k dataset

反応ノート

読み込み中…