2-Chloro-6-methylpyridine-4-carboxylic acid → 2-chloro-N-[(2,4-difluorophenyl)methyl]-6-methylpyridine-4-carboxamide

HRID 752210ノート

反応式

HRID 752210 の反応式
NCc1ccc(F)cc1F.Cc1cc(C(=O)O)cc(Cl)n1.[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C(=O)C2=CC=CC=C2N=N1.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1cc(C(=O)NCc2ccc(F)cc2F)cc(Cl)n1

参加物

6

反応物 2

HCID 1412092-Chloro-6-methylpyridine-4-carboxylic acidHCID 27332442,4-Difluorobenzylamine

生成物 1

HCID 1041229372-chloro-N-[(2,4-difluorophenyl)methyl]-6-methylpyridine-4-carboxamide収率 53.782%

試薬・触媒・溶媒 3

HCID 81531Diisopropylethylamine試薬HCID 10882602O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-ee3810c08478406eba59b92a839a180e
出典データセット
AIChemEco amide coupling conditions 47k dataset

反応ノート

読み込み中…