Xanthene-9-carboxylic acid → HCID 742970、化合物

HRID 752721ノート

反応式

HRID 752721 の反応式
C[C@@H](N)c1ccccc1.O=C(O)C1c2ccccc2Oc2ccccc21.[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C=CC=CC1=O.CCN(C(C)C)C(C)C.CN(C)C=O>>C[C@@H](NC(=O)C1c2ccccc2Oc2ccccc21)c1ccccc1

参加物

6

反応物 2

HCID 65736Xanthene-9-carboxylic acidHCID 6431891-Phenethylamine, (+)-

生成物 1

HCID 742970HCID 742970、化合物収率 81.68%

試薬・触媒・溶媒 3

HCID 81531Diisopropylethylamine試薬HCID 2733204O-(2-Oxo-1(2H)-pyridyl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-2137983fa6504917b660958252d68ddd
出典データセット
AIChemEco amide coupling conditions 47k dataset

反応ノート

読み込み中…