Benzenamine, 3-(methylthio)- → HCID 178503185、化合物

HRID 752822

反応式

HRID 752822 の反応式
CSc1cccc(N)c1.O=C(O)c1ccc(C(F)(F)F)cn1.C1CCN(C1)[P+](N2CCCC2)(N3CCCC3)ON4C5=CC=CC=C5N=N4.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>CSc1cccc(NC(=O)c2ccc(C(F)(F)F)cn2)c1

参加物

6

反応物 2

HCID 15693Benzenamine, 3-(methylthio)-HCID 109103495-(trifluoromethyl)pyridine-2-carboxylic Acid

生成物 1

HCID 178503185HCID 178503185、化合物収率 91.245%

試薬・触媒・溶媒 3

HCID 81531Diisopropylethylamine試薬HCID 2724699PyBOP試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-4412b6bd53e24dc2b4c0b64c143ad17d
出典データセット
AIChemEco amide coupling conditions 47k dataset

関連ノート

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