Acetyl chloride → HCID 178419001、化合物

HRID 7533

反応式

HRID 7533 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([NH2:9])[N:3]=1.[CH3:10][O:11][C:12](=[O:16])[CH2:13][N+:14]#[C-:15].[CH:17](=O)[C:18]1[O:22][CH:21]=[CH:20][CH:19]=1.[C:24](Cl)(=[O:26])[CH3:25]>Cl(O)(=O)(=O)=O>[Cl-:8].[C:24]([N+:1]1[C:17]([C:18]2[O:22][CH:21]=[CH:20][CH:19]=2)=[C:15]([NH:14][CH2:13][C:12]([O:11][CH3:10])=[O:16])[N:3]2[C:4]([NH2:9])=[CH:5][C:6]([Cl:8])=[N:7][C:2]=12)(=[O:26])[CH3:25]

参加物

6

反応物 4

HCID 6367Acetyl chlorideHCID 7362FurfuralHCID 674322,4-Diamino-6-chloropyrimidineHCID 547815Methyl isocyanoacetate

生成物 1

HCID 178419001HCID 178419001、化合物

試薬・触媒・溶媒 1

HCID 24247Perchloric Acid溶媒

実験手順

Example 27 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2,6-diamino-4-chloro-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) isocyanoacetic acid methyl ester solution (0.2 M, DCM), 0.500 ml (0.15 mmol) furfural solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

出典と根拠

ORDレコード
ord-e09d80b009c94883976bbcd98164aff7
出典データセット
uspto-grants-2006_08
特許番号
US07087607B2

関連ノート

読み込み中…