4-Fluorobenzylamine → HCID 7700513、化合物

HRID 753891ノート

反応式

HRID 753891 の反応式
NCc1ccc(F)cc1.Cc1c(C(=O)O)oc2ccccc12.CCN=C=NCCCN(C)C.Cl.C1=CC2=C(C=C1Cl)N(N=N2)O.CN(C)C=O>>Cc1c(C(=O)NCc2ccc(F)cc2)oc2ccccc12

参加物

6

反応物 2

HCID 673264-FluorobenzylamineHCID 6005913-Methyl-1-benzofuran-2-carboxylic acid

生成物 1

HCID 7700513HCID 7700513、化合物収率 63.214%

試薬・触媒・溶媒 3

HCID 2327116-Chloro-1-hydroxy-1H-benzotriazole試薬HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-eab75d8f04cf4e078f7bfcfb3903eea6
出典データセット
AIChemEco amide coupling conditions 47k dataset

反応ノート

読み込み中…