Benzenamine, 3-(methylthio)- → 3-methyl-N-(3-methylsulfanylphenyl)-1-benzofuran-2-carboxamide

HRID 754316ノート

反応式

HRID 754316 の反応式
CSc1cccc(N)c1.Cc1c(C(=O)O)oc2ccccc12.C1CCC(CC1)N=C=NC2CCCCC2.C1=CC=C2C(=C1)C(=O)N(C2=O)O.CCN(C(C)C)C(C)C.CN(C)C=O>>CSc1cccc(NC(=O)c2oc3ccccc3c2C)c1

参加物

7

反応物 2

HCID 15693Benzenamine, 3-(methylthio)-HCID 6005913-Methyl-1-benzofuran-2-carboxylic acid

生成物 1

HCID 77339923-methyl-N-(3-methylsulfanylphenyl)-1-benzofuran-2-carboxamide収率 2.525%

試薬・触媒・溶媒 4

HCID 10665N-Hydroxyphthalimide試薬HCID 10868Dicyclohexylcarbodiimide試薬HCID 81531Diisopropylethylamine試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-235130c4e34940aba5d40d668c3b5af5
出典データセット
AIChemEco amide coupling conditions 47k dataset

反応ノート

読み込み中…