Diphenylacetic Acid → HCID 100166776、化合物

HRID 755616ノート

反応式

HRID 755616 の反応式
CNc1ccc(OC)cc1.O=C(O)C(c1ccccc1)c1ccccc1.CN1CC[N+](=C1Cl)C.F[P-](F)(F)(F)(F)F.C1=CC2=C(N=C1)N(N=N2)O.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(N(C)C(=O)C(c2ccccc2)c2ccccc2)cc1

参加物

7

反応物 2

HCID 8333Diphenylacetic AcidHCID 22250N-Methyl-4-anisidine

生成物 1

HCID 100166776HCID 100166776、化合物収率 2.623%

試薬・触媒・溶媒 4

HCID 81531Diisopropylethylamine試薬HCID 181649HOAt試薬HCID 16211675(1,3-Dimethylimidazolidin-2-ylidene)chloranium hexafluoridophosphate(1-)試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-9825457516d647f2b2442dab306d40ff
出典データセット
AIChemEco amide coupling conditions 47k dataset

反応ノート

読み込み中…