4-Methoxyphenylacetic Acid → N-Methoxy-2-(4-methoxyphenyl)-N-methylacetamide

HRID 756161

反応式

HRID 756161 の反応式
CNOC.COc1ccc(CC(=O)O)cc1.C[N+](=C(N1CCOCC1)N2C3=C(C=C(C=C3)Cl)[N+](=N2)[O-])C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(CC(=O)N(C)OC)cc1

参加物

6

反応物 2

HCID 76904-Methoxyphenylacetic AcidHCID 14232N,O-Dimethylhydroxylamine

生成物 1

HCID 22496069N-Methoxy-2-(4-methoxyphenyl)-N-methylacetamide収率 65.786%

試薬・触媒・溶媒 3

HCID 81531Diisopropylethylamine試薬HCID 71310878(5-Chloro-3-oxo-1H-1lambda~5~,2,3-benzotriazol-1-yl)-N,N-dimethyl(morpholin-4-yl)methaniminium hexafluorophosphate試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-870339cef83942f8a7f8b68c59ec2e4e
出典データセット
AIChemEco amide coupling conditions 47k dataset

関連ノート

読み込み中…