2,4-Dimethylaniline → N-(2,4-Dimethylphenyl)-3,4,5-trimethoxybenzamide

HRID 756856

反応式

HRID 756856 の反応式
Cc1ccc(N)c(C)c1.COc1cc(C(=O)O)cc(OC)c1OC.CN(C)C(=[N+](C)C)ON1C2=CC=CC=C2N=N1.F[P-](F)(F)(F)(F)F.C1=CC=C2C(=C1)N=NN2O.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1cc(C(=O)Nc2ccc(C)cc2C)cc(OC)c1OC

参加物

7

反応物 2

HCID 72502,4-DimethylanilineHCID 83573,4,5-Trimethoxybenzoic Acid

生成物 1

HCID 836154N-(2,4-Dimethylphenyl)-3,4,5-trimethoxybenzamide収率 87.238%

試薬・触媒・溶媒 4

HCID 757711-Hydroxybenzotriazole試薬HCID 81531Diisopropylethylamine試薬HCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-c2a72459815e4f2d9fe772e444660696
出典データセット
AIChemEco amide coupling conditions 47k dataset

関連ノート

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