Formamide → 7-Fluoroquinazolin-4(3H)-one

HRID 75707

反応式

HRID 75707 の反応式
[NH2:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:12]([NH2:14])=O>CN(C)C=O>[F:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4](=[O:5])[NH:14][CH:12]=[N:1]2)=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 713FormamideHCID 27249674-Fluoroanthranilic acid

生成物 1

HCID 1353984967-Fluoroquinazolin-4(3H)-one収率 81.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
180 °C

実験手順

2-amino-4-fluorobenzoic acid (100 g, 0.64 mol) and formamide (154 mL, 3.87 mol) were mixed with a catalytic amount (1 mL) of N,N-dimethylformamide. The mixture was heated to 180° C. and further stirred for 14 hours. The mixture was cooled to room temperature, and distilled water (1000 mL) was added thereto. The mixture was stirred for 30 min and filtered to obtain the title compound (86 g, 81.3%).

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. distillationdistilled water (1000 mL)
  3. additionwas added
  4. stirringThe mixture was stirred for 30 min
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-25bcd9b5e8a44c889d87d8e953462ed9
出典データセット
uspto-grants-2014_09
特許番号
US08835458B2

関連ノート

読み込み中…