関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Formamide | HCID 713 | — |
| 反応物 | 4-Fluoroanthranilic acid | HCID 2724967 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 7-Fluoroquinazolin-4(3H)-one | HCID 135398496 | 81.9% |
反応手順
2-amino-4-fluorobenzoic acid (100 g, 0.64 mol) and formamide (154 mL, 3.87 mol) were mixed with a catalytic amount (1 mL) of N,N-dimethylformamide. The mixture was heated to 180° C. and further stirred for 14 hours. The mixture was cooled to room temperature, and distilled water (1000 mL) was added thereto. The mixture was stirred for 30 min and filtered to obtain the title compound (86 g, 81.3%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08835458B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-25bcd9b5e8a44c889d87d8e953462ed9 |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
