Nitric Acid → 4-(Benzyloxy)-5-methoxy-2-nitrobenzaldehyde

HRID 75711

反応式

HRID 75711 の反応式
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=[O:14])=[CH:11][C:10]=1[O:17][CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:19]([O-])([OH:21])=[O:20]>>[CH2:1]([O:8][C:9]1[C:10]([O:17][CH3:18])=[CH:11][C:12]([CH:13]=[O:14])=[C:15]([N+:19]([O-:21])=[O:20])[CH:16]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 944Nitric AcidHCID 755064-(Benzyloxy)-3-methoxybenzaldehyde

生成物 1

HCID 5613634-(Benzyloxy)-5-methoxy-2-nitrobenzaldehyde収率 87%

実験手順

Nitric acid (100 mL) was cooled to 0° C., 4-benzyloxy-3-methoxybenzaldehyde (20 g, 82.55 mmol) was added dropwise, and the mixture was stirred at room temperature for 2 hours. After completion of the reaction, distilled water was added thereto and the mixture was stirred for 30 min, followed by filtration of the solid to obtain the title compound (20.52 g, 87%).

後処理

  1. customAfter completion of the reaction
  2. distillationdistilled water
  3. additionwas added
  4. stirringthe mixture was stirred for 30 min
  5. filtrationfollowed by filtration of the solid

出典と根拠

ORDレコード
ord-829124fe01be4f0d845d1c70aca583ab
出典データセット
uspto-grants-2014_09
特許番号
US08835458B2

関連ノート

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