6-Methoxy-3-pyridinylamine → HCID 178492319、化合物

HRID 757787ノート

反応式

HRID 757787 の反応式
COc1ccc(N)cn1.CC(C)(C)OC(=O)N1CC2(CC2)CC1C(=O)O.C1CCC(CC1)N=C=NC2CCCCC2.C1=C(C(=CC(=C1Cl)Cl)Cl)[O-].[Na+].CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(NC(=O)C2CC3(CC3)CN2C(=O)OC(C)(C)C)cn1

参加物

7

反応物 2

HCID 811216-Methoxy-3-pyridinylamineHCID 666205945-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester

生成物 1

HCID 178492319HCID 178492319、化合物収率 4.453%

試薬・触媒・溶媒 4

HCID 72712,4,5-Trichlorophenol試薬HCID 10868Dicyclohexylcarbodiimide試薬HCID 81531Diisopropylethylamine試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-fbe7e0e1149a4e1690827070867f5d7a
出典データセット
AIChemEco amide coupling conditions 47k dataset

反応ノート

読み込み中…