4-(2-Methylbutan-2-yl)benzene-1-sulfonyl chloride → n-(4-Chloro-2-[1,2,3]triazolo[4,5-b]pyridin-1-yl-phenyl)-4-(1,1-dimethyl-propyl)-benzenesulfonamide

HRID 75991

反応式

HRID 75991 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([N:9]2[C:17]3[C:12](=[N:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[N:10]2)[CH:3]=1.[CH3:18][C:19]([C:23]1[CH:28]=[CH:27][C:26]([S:29](Cl)(=[O:31])=[O:30])=[CH:25][CH:24]=1)([CH3:22])[CH2:20][CH3:21]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:29]([C:26]2[CH:27]=[CH:28][C:23]([C:19]([CH3:18])([CH3:22])[CH2:20][CH3:21])=[CH:24][CH:25]=2)(=[O:31])=[O:30])=[C:4]([N:9]2[C:17]3[C:12](=[N:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[N:10]2)[CH:3]=1

参加物

4

反応物 2

HCID 222819764-(2-Methylbutan-2-yl)benzene-1-sulfonyl chlorideHCID 594281144-Chloro-2-[1,2,3]triazolo[4,5-b]pyridin-1-yl-phenylamine

生成物 1

HCID 25135042n-(4-Chloro-2-[1,2,3]triazolo[4,5-b]pyridin-1-yl-phenyl)-4-(1,1-dimethyl-propyl)-benzenesulfonamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A 4 mL scintillation vial was charged with 4-chloro-2-[1,2,3]triazolo[4,5-b]pyridin-1-yl-phenylamine (100 mg, 0.363 mmol), 4-(1,1-dimethyl-propyl)-benzenesulfonyl chloride (98 g, 0.399 mmol), and pyridine (1 mL). The resultant solution was stirred 4 hours at 80° C. and then partitioned with EtOAc/1 M HCl. The organics were subsequently washed with 1 M HCl, saturated aqueous sodium bicarbonate, and brine; dried over anhydrous sodium sulfate; and removed in vacuo. The resultant residue was then purified via automated silica gel chromatography to afford the desired sulfonamide: MS (ES) M+H expected 456.2, found 456.3.

後処理

  1. custompartitioned with EtOAc/1 M HCl
  2. washThe organics were subsequently washed with 1 M HCl, saturated aqueous sodium bicarbonate, and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customand removed in vacuo
  5. customThe resultant residue was then purified

出典と根拠

ORDレコード
ord-675f9c9f37914158a540573c6559152c
出典データセット
uspto-grants-2014_09
特許番号
US08835468B2

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