4-[2-(1-Phenyl-ethylamino)-propyl]-phenol → Hydroxyamfetamine

HRID 76151ノート

反応式

HRID 76151 の反応式
C1(C([NH:9][CH:10]([CH3:19])[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)C)C=CC=CC=1.[H][H]>[OH-].[Pd+2].[OH-].CO>[NH2:9][CH:10]([CH3:19])[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1

参加物

5

反応物 2

HCID 220871554-[2-(1-Phenyl-ethylamino)-propyl]-phenolHCID 178418361HCID 178418361、化合物

生成物 1

HCID 3651Hydroxyamfetamine

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

5.80 g (20.0 mmol) 4-[2-(1-phenyl-ethylamino)-propyl]-phenol (I37) are added to 300 mL MeOH and charged with 0.60 g palladiumhydroxide (20%) on activated carbon. The mixture is stirred in a hydrogen atmosphere (50 psi) at 50° C. for 1 h 15 min. Then the mixture is filtrated, the solvent is removed in vacuo and the residue is triturated diethylether. The residue is dried at 80° C. in vacuo.

後処理

  1. filtrationThen the mixture is filtrated
  2. customthe solvent is removed in vacuo
  3. customthe residue is triturated diethylether
  4. customThe residue is dried at 80° C. in vacuo

出典と根拠

ORDレコード
ord-4c1bf37414c0430da877f3882c7d240d
出典データセット
uspto-grants-2014_09
特許番号
US08835472B2

反応ノート

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