Sodium cyanoborohydride → 1-(4-Iodophenyl)butan-2-amine
反応式
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=O)[CH2:10][CH3:11])=[CH:4][CH:3]=1.[BH3-]C#[N:15].[Na+]>CC(O)C>[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH2:15])[CH2:10][CH3:11])=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 90 °C
実験手順
5.95 g (21.7 mmol) 1-(4-iodophenyl)-butane-2-one (I39) are added to 150 mL 2-propanol and transferred into an autoclav. 25.1 g (326 mmol) NH4OAc and 4.09 g (65.1 mmol) NaCNBH3 are added and the mixture is stirred at 90° C. over night. The reaction is quenched by the addition of sat. aq. NaHCO3 solution and extracted with EtOAc (3×). The combined organic layers are washed with brine, dried with Na2SO4 and the solvent is removed in vacuo. The compound is used without further purification.
後処理
- customThe reaction is quenched by the addition of sat. aq. NaHCO3 solution
- extractionextracted with EtOAc (3×)
- washThe combined organic layers are washed with brine
- dry with materialdried with Na2SO4
- customthe solvent is removed in vacuo
- customThe compound is used without further purification
出典と根拠
- ORDレコード
- ord-47e8aff04b724365b6255ef04f73b62f
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08835472B2
反応ノート
読み込み中…