Ethanol → 2-Oxopyrrolidine-3-carboxylic acid

HRID 76181

反応式

HRID 76181 の反応式
C(OC([N:6]1[CH2:10][CH2:9][CH2:8][C:7]1=[O:11])=O)C.[OH-:12].[Na+].C[CH2:15][OH:16]>>[O:11]=[C:7]1[CH:8]([C:15]([OH:16])=[O:12])[CH2:9][CH2:10][NH:6]1

参加物

4

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 234959Ethyl 2-oxopyrrolidine-1-carboxylate

生成物 1

HCID 134743702-Oxopyrrolidine-3-carboxylic acid

実験手順

To 0.50 g (3.18 mmol) 2-oxo-pyrollidine-carboxylic acid ethyl ester in 10 mL EtOH are added 5 mL aq. NaOH (1M) solution. The reaction mixture is stirred at r.t. for 3 h. The EtOH is removed in vacuo and the residue is diluted with water and acidified with aq. HCl (2M) solution. The resulting precipitate is filtered and dried.

後処理

  1. customThe EtOH is removed in vacuo
  2. additionthe residue is diluted with water
  3. filtrationThe resulting precipitate is filtered
  4. customdried

出典と根拠

ORDレコード
ord-eb7275050f334e848da4cf494465570b
出典データセット
uspto-grants-2014_09
特許番号
US08835472B2

関連ノート

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