1-Ethoxy-4-ethynylbenzene → N-(4-((4-Ethoxyphenyl)ethynyl)phenethyl)propionamide

HRID 76195

反応式

HRID 76195 の反応式
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]#[CH:11])=[CH:6][CH:5]=1)[CH3:2].I[C:13]1[CH:25]=[CH:24][C:16]([CH2:17][CH2:18][NH:19][C:20](=[O:23])[CH2:21][CH3:22])=[CH:15][CH:14]=1>O.C(N)(CC)C.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]#[C:11][C:13]2[CH:25]=[CH:24][C:16]([CH2:17][CH2:18][NH:19][C:20](=[O:23])[CH2:21][CH3:22])=[CH:15][CH:14]=2)=[CH:6][CH:5]=1)[CH3:2]

参加物

6

反応物 2

HCID 27751241-Ethoxy-4-ethynylbenzeneHCID 66611251N-(4-iodophen-ethyl)propionamide

生成物 1

HCID 66611159N-(4-((4-Ethoxyphenyl)ethynyl)phenethyl)propionamide

試薬・触媒・溶媒 3

HCID 178418476HCID 178418476、化合物触媒HCID 962Water溶媒HCID 24874Sec-Butylamine溶媒

実験手順

150 mg (1.03 mmol) 1-ethoxy-4-ethynylbenzene, 327 mg (1.08 mmol) N-(4-iodophen-ethyl)propionamide (I47.2) and 36 mg (0.05 mmol) bis(triphenylphosphine)dichloro-palladium in 2.0 mL water and 1.5 mL sec-butylamine are stirred at r.t. over night and for additional 4 h at 30° C. The reaction mixture is partitioned between DCM and water. The solvent of the organic layer is evaporated in vacuo and the residue is purified by HPLC (MeOH/H2O/NH3).

後処理

  1. customThe reaction mixture is partitioned between DCM and water
  2. customThe solvent of the organic layer is evaporated in vacuo
  3. customthe residue is purified by HPLC (MeOH/H2O/NH3)

出典と根拠

ORDレコード
ord-02e93700f2474a85ae967845e3e81f03
出典データセット
uspto-grants-2014_09
特許番号
US08835472B2

関連ノート

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