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1-Ethoxy-4-ethynylbenzene → N-(4-((4-Ethoxyphenyl)ethynyl)phenethyl)propionamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Ethoxy-4-ethynylbenzene | HCID 2775124 | — |
| 反応物 | N-(4-iodophen-ethyl)propionamide | HCID 66611251 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Sec-Butylamine | HCID 24874 | — |
| 生成物 | N-(4-((4-Ethoxyphenyl)ethynyl)phenethyl)propionamide | HCID 66611159 | — |
反応手順
150 mg (1.03 mmol) 1-ethoxy-4-ethynylbenzene, 327 mg (1.08 mmol) N-(4-iodophen-ethyl)propionamide (I47.2) and 36 mg (0.05 mmol) bis(triphenylphosphine)dichloro-palladium in 2.0 mL water and 1.5 mL sec-butylamine are stirred at r.t. over night and for additional 4 h at 30° C. The reaction mixture is partitioned between DCM and water. The solvent of the organic layer is evaporated in vacuo and the residue is purified by HPLC (MeOH/H2O/NH3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08835472B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-02e93700f2474a85ae967845e3e81f03 |
| 出典メモ | uspto-grants-2014_09 |