Triethylamine → HCID 178418938、化合物

HRID 7623

反応式

HRID 7623 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([Cl:9])[N:3]=1.[NH2:10][C:11]1[CH:15]=[C:14]([CH:16]2[CH2:18][CH2:17]2)[NH:13][N:12]=1.C(N(CC)CC)C>CCO>[CH:16]1([C:14]2[CH:15]=[C:11]([NH:10][C:6]3[CH:5]=[C:4]([Cl:9])[N:3]=[C:2]([Cl:1])[N:7]=3)[NH:12][N:13]=2)[CH2:18][CH2:17]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 773782,4,6-TrichloropyrimidineHCID 27580143-cyclopropyl-1H-pyrazol-5-amine

生成物 1

HCID 178418938HCID 178418938、化合物収率 80%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of-2,4,6-trichloropyrimidine (600 mg, 3.27 mmol) and 3-amino-5-cyclopropylpyrazole (403 mg, 3.27 mmol) in EtOH (10 mL) was added triethylamine (456 μL, 3.27 mmol) and the reaction mixture was stirred for 15 hours at room temperature. The solvent was evaporated and the residue was purified by flash chromatography (SiO2, Hexane/AcOEt gradient) to afford (5-cyclopropyl-2H-pyrazol-3-yl-)-(2,6-dichloropyrimidin-4-yl)-amine (705 mg, 80%).

後処理

  1. customThe solvent was evaporated
  2. customthe residue was purified by flash chromatography (SiO2, Hexane/AcOEt gradient)

出典と根拠

ORDレコード
ord-35c861d6b82946f599930c0c25b7c1b1
出典データセット
uspto-grants-2006_08
特許番号
US07087603B2

関連ノート

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