Triethylamine → HCID 178418938、化合物
反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([Cl:9])[N:3]=1.[NH2:10][C:11]1[CH:15]=[C:14]([CH:16]2[CH2:18][CH2:17]2)[NH:13][N:12]=1.C(N(CC)CC)C>CCO>[CH:16]1([C:14]2[CH:15]=[C:11]([NH:10][C:6]3[CH:5]=[C:4]([Cl:9])[N:3]=[C:2]([Cl:1])[N:7]=3)[NH:12][N:13]=2)[CH2:18][CH2:17]1参加物
5
実験手順
To a solution of-2,4,6-trichloropyrimidine (600 mg, 3.27 mmol) and 3-amino-5-cyclopropylpyrazole (403 mg, 3.27 mmol) in EtOH (10 mL) was added triethylamine (456 μL, 3.27 mmol) and the reaction mixture was stirred for 15 hours at room temperature. The solvent was evaporated and the residue was purified by flash chromatography (SiO2, Hexane/AcOEt gradient) to afford (5-cyclopropyl-2H-pyrazol-3-yl-)-(2,6-dichloropyrimidin-4-yl)-amine (705 mg, 80%).
後処理
- customThe solvent was evaporated
- customthe residue was purified by flash chromatography (SiO2, Hexane/AcOEt gradient)
出典と根拠
- ORDレコード
- ord-35c861d6b82946f599930c0c25b7c1b1
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087603B2
反応ノート
読み込み中…