1-((Tert-butoxy)carbonyl)pyrrolidine-3-carboxylic acid → HCID 178441299、化合物

HRID 76288

反応式

HRID 76288 の反応式
[C:1]([N:5]1[CH:9]=[C:8]([CH2:10][CH2:11][CH2:12][CH3:13])[C:7](=[NH:14])[S:6]1)([CH3:4])([CH3:3])[CH3:2].[C:15]([O:19][C:20]([N:22]1[CH2:26][CH2:25][CH:24]([C:27](O)=[O:28])[CH2:23]1)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[CH2:10]([C:8]1=[CH:9][N:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[S:6]/[C:7]/1=[N:14]\[C:27]([CH:24]1[CH2:25][CH2:26][N:22]([C:20]([O:19][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:21])[CH2:23]1)=[O:28])[CH2:11][CH2:12][CH3:13]

参加物

3

反応物 2

HCID 27605291-((Tert-butoxy)carbonyl)pyrrolidine-3-carboxylic acidHCID 668672282-tert-Butyl-4-butylisothiazol-5(2H)-imine

生成物 1

HCID 178441299HCID 178441299、化合物

実験手順

The product from Example 92B and 1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (Aldrich) were processed using the method described in Example 92C to afford the title compound. 1H NMR (DMSO-d6) δ 0.91 (t, J=7.3 Hz, 3H), 1.27-1.35 (m, 2H), 1.39 (s, 9H), 1.55-1.65 (m, 12H), 2.06-2.11 (m, 2H), 2.62-2.67 (m, 2H), 3.19-3.30 (m, 2H), 3.45-3.54 (m, 2H), 8.56 (s, 1H). MS (ESI+) m/z 410 (M+H)+.

出典と根拠

ORDレコード
ord-94aae191121d4af896ac3878ac76f912
出典データセット
uspto-grants-2014_09
特許番号
US08835475B2

関連ノート

読み込み中…