Triethylamine → Ethyl N-(4-chloro-2-pyrimidinyl)-N-methylglycinate
反応式
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.[CH3:9][NH:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].C(N(CC)CC)C>O1CCOCC1>[Cl:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:10]([CH3:9])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:7]=1参加物
5
実験手順
30.0 g (0.20 mol) of 2,4-dichloropyrimidine, 30.9 g (0.20 mol) of ethyl N-methylglycinate and 61.0 g (0.60 mol) of triethylamine in 200 ml of dioxane are stirred at 50° C. for 10 min. The mixture is filtered off with suction and the mother liquor is concentrated to half the original volume. A solid crystallizes out, which is filtered off with suction. The mother liquor is concentrated, the residue is stirred with petroleum ether and the product is filtered off.
後処理
- filtrationThe mixture is filtered off with suction
- concentrationthe mother liquor is concentrated to half the original volume
- customA solid crystallizes out, which
- filtrationis filtered off with suction
- concentrationThe mother liquor is concentrated
- filtrationthe product is filtered off
出典と根拠
- ORDレコード
- ord-8cdd1682398d44799c23b12882d311f3
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087616B2
反応ノート
読み込み中…