Butanoic acid, 2-bromo-, ethyl ester → 8-bromo-2-ethyl-2H-benzo[b][1,4]oxazin-3(4H)-one
反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[C:3]=1[OH:9].N12CCCN=C1CCCCC2.[CH3:21][CH2:22][CH:23](Br)[C:24](OCC)=[O:25]>CN1CCCC1=O>[Br:1][C:2]1[C:3]2[O:9][CH:23]([CH2:22][CH3:21])[C:24](=[O:25])[NH:8][C:4]=2[CH:5]=[CH:6][CH:7]=1参加物
5
実験手順
Procedure & NMR Data: 1.5 g (7.9 mmol) of 2-bromo-6-aminophenol, 1.08 ml (0.9 eq, 7.11 mmol) of 1.8-diazabicyclo[5.4.0]undec-7-ene and 3.5 mL of DL-Ethyl 2-bromobutyrate (3 eq, 23.7 mmol)) in 30 mL of 1-Methyl-2-pyrrolidinone were mixed. 1.447 g of P1 were obtained, yield 71%.
後処理
- custom1.447 g of P1 were obtained
出典と根拠
- ORDレコード
- ord-efd9c31ad02147a0b0605978b604591c
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08835628B2
反応ノート
読み込み中…