N-(2,2-difluoroethyl)-2-nitroaniline → N-(2,2-difiuoroethyl)benzene-1,2-diamine

HRID 76359

反応式

HRID 76359 の反応式
[F:1][CH:2]([F:14])[CH2:3][NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N+:11]([O-])=O>CO.[Pd]>[F:1][CH:2]([F:14])[CH2:3][NH:4][C:5]1[C:6]([NH2:11])=[CH:7][CH:8]=[CH:9][CH:10]=1

参加物

4

反応物 1

HCID 58110950N-(2,2-difluoroethyl)-2-nitroaniline

生成物 1

HCID 58110951N-(2,2-difiuoroethyl)benzene-1,2-diamine収率 97.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 3.6 g (18 mM) of N-(2,2-difluoroethyl)-2-nitroaniline in 25 ml of methanol, were added 470 mg of palladium on carbon at 5%. The reaction mixture was stirred for 3 h at room temperature under hydrogen atmosphere, at room pressure and room temperature. The catalyst was filtrated on Celite and the filtrate was evaporated under vacuum to give 3 g of N-(2,2-difluoroethyl)benzene-1,2-diamine as an oil. Yield: 97.5%.

後処理

  1. filtrationThe catalyst was filtrated on Celite
  2. customthe filtrate was evaporated under vacuum

出典と根拠

ORDレコード
ord-822ae9bbc4524223ac08e97fa7569401
出典データセット
uspto-grants-2014_09
特許番号
US08835634B2

関連ノート

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