2,4-Dichloro-5-fluoropyrimidine → 2-chloro-5-fluoro-N4-[(1H)indol-6-yl]-4-pyrimidineamine

HRID 76431

反応式

HRID 76431 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[NH2:10][C:11]1[CH:19]=[C:18]2[C:14]([CH:15]=[CH:16][NH:17]2)=[CH:13][CH:12]=1>>[Cl:1][C:2]1[N:7]=[C:6]([NH:10][C:11]2[CH:19]=[C:18]3[C:14]([CH:15]=[CH:16][NH:17]3)=[CH:13][CH:12]=2)[C:5]([F:9])=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 2560966-Aminoindole

生成物 1

HCID 220604592-chloro-5-fluoro-N4-[(1H)indol-6-yl]-4-pyrimidineamine

実験手順

In a like manner to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine, 2,4-dichloro-5-fluoropyrimidine and 6-aminoindole were reacted to provide 2-chloro-5-fluoro-N4-[(1H)-indol-6-yl]-4-pyrimidineamine. LCMS: purity: 92%; MS (m/e): 263 (MH+).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-0643f1ee8eee49c0a08ab668f6b3a44b
出典データセット
uspto-grants-2014_09
特許番号
US08835430B2

関連ノート

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