4-Ethylaniline → N2,N4-bis(4-ethylphenyl)-5-fluoro-2,4-pyrimidinediamine

HRID 76505

反応式

HRID 76505 の反応式
O[C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]=[C:13]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18](O)[CH:17]=3)[C:12]([F:23])=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.ClC1N=[C:29](Cl)[C:28](F)=CN=1.[CH2:33](C1C=CC(N)=CC=1)[CH3:34]>>[CH2:33]([C:7]1[CH:6]=[CH:5][C:4]([NH:8][C:9]2[N:14]=[C:13]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([CH2:28][CH3:29])=[CH:18][CH:17]=3)[C:12]([F:23])=[CH:11][N:10]=2)=[CH:3][CH:2]=1)[CH3:34]

参加物

4

反応物 3

HCID 115044-EthylanilineHCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 9904854R-112

生成物 1

HCID 22060330N2,N4-bis(4-ethylphenyl)-5-fluoro-2,4-pyrimidinediamine

実験手順

In a manner similar to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 4-ethylaniline were reacted to yield N2,N4-bis(4-ethylphenyl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CDCl3): δ 8.83 (bs, 1H), 7.77 (d, 1H, J=3.9 Hz), 7.48 (d, 2H, J=8.7 Hz), 7.40 (d, 2H, J=8.7 Hz), 7.31 (bs, 1H), 7.18 (d, 2H, J=8.7 Hz), 7.11 (d, 2H, J=8.7 Hz), 2.68-2.61 (m, 4H), 1.28-1.21 (m, 6H); LCMS: ret. time: 29.17 min.; purity: 100%; MS (m/e): 337 (MH+).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-85478dbaaaf54ccebba8d2842146f6b8
出典データセット
uspto-grants-2014_09
特許番号
US08835430B2

関連ノート

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