Thionyl Chloride → 1-(Benzyloxy)-4-(tert-butyl)-2-(chloromethyl)benzene

HRID 76777ノート

反応式

HRID 76777 の反応式
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:13][C:10]=1[CH2:11]O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=S(Cl)[Cl:23]>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:13][C:10]=1[CH2:11][Cl:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 59544156(2-(Benzyloxy)-5-(tert-butyl)phenyl)methanol

生成物 1

HCID 595441551-(Benzyloxy)-4-(tert-butyl)-2-(chloromethyl)benzene

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
20 °C

実験手順

To a stirred solution of compound 4 (963 g, 3.56 mol) in anhydrous DCM (2000 mL) was added slowly SOCl2 (535 g, 4.5 mol) at 0° C. The mixture was stirred at 20° C. for 2 hours, then concentrated in vacuo to give compound 5 as an oil, which was used in the next reaction without further drying or purification.

後処理

  1. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-959544ec7cb143c48a8ef9cf375f0f66
出典データセット
uspto-grants-2014_09
特許番号
US08835639B2

反応ノート

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