Ammonia → 2-Amino-3,3-dimethylbutanoic acid

HRID 76843

反応式

HRID 76843 の反応式
[OH-].[Na+].[NH2:3][C@@H:4]([C:9]([OH:11])=[O:10])[C:5]([CH3:8])([CH3:7])[CH3:6].[OH-].[NH4+].N>>[NH2:3][CH:4]([C:9]([OH:11])=[O:10])[C:5]([CH3:8])([CH3:7])[CH3:6]

参加物

5

反応物 4

HCID 222AmmoniaHCID 14798Sodium HydroxideHCID 14923Ammonium HydroxideHCID 6950340D-tert-leucine

生成物 1

HCID 3061312-Amino-3,3-dimethylbutanoic acid

実験手順

A process was developed to racemize D-tert-leucine so that it can be recycled. Use of acids, although caused racemization, resulted in salt formation. It was tedious to obtain free amino acid from such salts. The same drawback was observed when a strong base such as sodium hydroxide was used. However, treating D-tert-leucine with ammonium hydroxide resulted in complete racemization. The reaction has to be conducted at about 80° C. for about 12 hours in an autoclave to prevent the escape of ammonia. The solvent is removed at 55° C. (±5) under reduced pressure to obtain DL-tert-leucine. After the reaction, although ammonium salt of DL-tent-leucine is obtained, during the removal of the solvent, ammonia also is eliminated and free amino acid is obtained.

後処理

  1. customresulted in complete racemization
  2. customThe solvent is removed at 55° C. (±5) under reduced pressure

出典と根拠

ORDレコード
ord-c4857fc2c7fa4557abce9b560a7bf2c7
出典データセット
uspto-grants-2014_09
特許番号
US08835676B2

関連ノート

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