Oxalyl chloride → 6-Heptenoyl chloride

HRID 76910

反応式

HRID 76910 の反応式
[C:1]([OH:9])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]=[CH2:7].C(Cl)(=O)C([Cl:13])=O>C(Cl)Cl.CN(C=O)C>[C:1]([Cl:13])(=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]=[CH2:7]

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 707056-Heptenoic acid

生成物 1

HCID 108556156-Heptenoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of 6-heptenoic acid (251 μL, 1.85 mmol) in CH2Cl2 (5 mL) at rt was added oxalyl chloride (476 μL, 5.55 mmol) and DMF (1 drop). After stirring for 1 hr, the reaction mixture was concentrated under reduced pressure and put under high vacuum for 15 min. The residual yellow oil was dissolved in CH2Cl2 (3 mL) and used as a stock solution (0.62M) for the subsequent acylation reactions.

後処理

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. waitput under high vacuum for 15 min
  3. dissolutionThe residual yellow oil was dissolved in CH2Cl2 (3 mL)

出典と根拠

ORDレコード
ord-f83d34427ecc4f969b904b95bb6636c5
出典データセット
uspto-grants-2014_09
特許番号
US08835693B2

関連ノート

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