2-Oxazolidinone → 4-[2-(2-Oxo-1,3-oxazolidin-3-yl)-1,3-thiazol-4-yl]benzonitrile
反応式
N#Cc1ccc(-c2csc(Br)n2)cc1.O=C1NCCO1>C1COCCO1.CC(=O)O.CC(=O)O.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.O=C([O-])[O-].[Cs+].[Cs+].[Pd]>N#Cc1ccc(-c2csc(N3CCOC3=O)n2)cc1参加物
7
反応条件
- 温度
- 150 °C
実験手順
4-(2-bromothiazol-4-yl)benzonitrile (100 mg, 0.38 mmol), 2-Oxazolidinone (49.3 mg, 0.57 mmol), diacetoxypalladium (5.93 mg, 0.03 mmol), cesium carbonate (369 mg, 1.13 mmol), water (10 µl) and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (21.82 mg, 0.04 mmol) were suspended in dioxane (2 mL), thoroughly degassed and sealed into a microwave tube and stirred at RT for 20 mins. The reaction was then heated to 150 °C for 10 minutes in the microwave reactor and cooled to RT. Load of rubbish... ABANDONED
出典と根拠
- ORDレコード
- ord-b8e52e6f1bc8459e8364a7285d41ce7c
- 出典データセット
- 750 AstraZeneca ELN dataset
- 元リンク
- 出典を表示
反応ノート
読み込み中…
