Sorbitol → Tamsulosin

HRID 77254

反応式

HRID 77254 の反応式
[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][NH:13][C@@H:14]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([O:27][CH3:28])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1)[CH3:15].Cl.OC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O>>[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][NH:13][C@@H:14]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([O:27][CH3:28])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1)[CH3:15]

参加物

3

反応物 2

HCID 5780SorbitolHCID 5362376Tamsulosin Hydrochloride

生成物 1

HCID 129211Tamsulosin

実験手順

An amount of 36.3 mg Tamsulosin hydrochloride was added at 60° C. to 50 ml of aqueous solution containing 1.5 g of sodium alginate (Protanal LF, FMC Biopolymer) and 350 mg of sorbitol. The resulting solution was cast on two 9 cm-diameter polyester Petri dishes and dried at ambient temperature under constant airflow in a chemical hood. The dried film was tested for oral disintegration acceptance (taste, adhesion and disintegration rate). The film was found to have slight bitter taste, to have good adhesion to roof of the mouth, and oral cavity disintegration of less then one minute.

後処理

  1. customdried at ambient temperature under constant airflow in a chemical hood
  2. customone minute

出典と根拠

ORDレコード
ord-c9f14c7c0b48445382f19a3e7f472edc
出典データセット
uspto-grants-2014_09
特許番号
US08840935B2

関連ノート

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