Citric Acid → Escitalopram

HRID 77255

反応式

HRID 77255 の反応式
C(O)(=O)CC(CC(O)=O)(C(O)=O)O.C(O)[C@H]1O[C@H](O[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O.COC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC1C=CC=CC=1)=O.[CH3:58][N:59]([CH2:61][CH2:62][CH2:63][C@@:64]1([C:75]2[CH:76]=[CH:77][C:78]([F:81])=[CH:79][CH:80]=2)[O:72][CH2:71][C:70]2[CH:69]=[C:68]([C:73]#[N:74])[CH:67]=[CH:66][C:65]1=2)[CH3:60].C(O)(C(O)=O)=O>O.OCC(CO)O>[CH3:58][N:59]([CH2:61][CH2:62][CH2:63][C@@:64]1([C:75]2[CH:80]=[CH:79][C:78]([F:81])=[CH:77][CH:76]=2)[O:72][CH2:71][C:70]2[CH:69]=[C:68]([C:73]#[N:74])[CH:67]=[CH:66][C:65]1=2)[CH3:60]

参加物

7

反応物 4

HCID 311Citric AcidHCID 5988SucroseHCID 134601AspartameHCID 146571Escitalopram Oxalate

生成物 1

HCID 146570Escitalopram

試薬・触媒・溶媒 2

HCID 753Glycerol溶媒HCID 962Water溶媒

実験手順

The composition of the formulation and the amounts of the ingredients are shown in the table below. Citric acid was dissolved in 200 ml of distilled water and then sodium alginate (Protanal LF10/60, FMC Biopolymer), glycerol and sucrose were added and dissolved at 60° C. The obtained solution was cooled to ambient temperature and, then, Aspartame, Escitalopram Oxalate and Fantasy flavor were added and dissolved therein. The resulting solution was cast onto casting mold having casting area of 1,150 cm2 and dried according to Example 3.

後処理

  1. dissolutiondissolved at 60° C
  2. dissolutiondissolved
  3. customdried

出典と根拠

ORDレコード
ord-e1b8f4cebdf942f3a50951d8c18284b7
出典データセット
uspto-grants-2014_09
特許番号
US08840935B2

関連ノート

読み込み中…