Triethylamine → (E)-N-(4-(difluoromethoxy)phenyl)-6-(2-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)vinyl)pyridazin-3-amine

反応式

I[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][O:12]1)[N:6]=[CH:5]2.[F:17][CH:18]([F:35])[O:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27]2[N:28]=[N:29][C:30]([CH:33]=[CH2:34])=[CH:31][CH:32]=2)=[CH:22][CH:21]=1.C1(C)C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C.C(N(CC)CC)C>C(#N)C.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C(Cl)(Cl)Cl.[Pd].[Pd]>[F:35][CH:18]([F:17])[O:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27]2[N:28]=[N:29][C:30](/[CH:33]=[CH:34]/[C:2]3[CH:3]=[C:4]4[C:8](=[CH:9][CH:10]=3)[N:7]([CH:11]3[CH2:16][CH2:15][CH2:14][CH2:13][O:12]3)[N:6]=[CH:5]4)=[CH:31][CH:32]=2)=[CH:22][CH:21]=1