Hydrochloric Acid → 3-(4-Bromo-pyrazol-1-yl)-pyridin-2-ylamine
反応式
[Br:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[C:8]([NH:13]C(=O)C(C)(C)C)=[N:9][CH:10]=[CH:11][CH:12]=2)[CH:6]=1.Cl.[OH-].[Na+]>>[Br:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[C:8]([NH2:13])=[N:9][CH:10]=[CH:11][CH:12]=2)[CH:6]=1参加物
4
反応条件
- 温度
- 105 °C
実験手順
A mixture of N-(3-(4-bromo-pyrazol-1-yl)-pyridin-2-yl)-2,2-dimethyl-propionamide (380 mg, 1.2 mmol) described in Manufacturing Example 39-1-3 and aqueous 2.5 N hydrochloric acid solution (2 mL) was stirred overnight at 105° C. The reaction mixture was cooled to 0° C., and 5 N sodium hydroxide solution (1 mL) was added. The resulting solids were filtered to obtain the title compound (100 mg, 72%).
後処理
- temperatureThe reaction mixture was cooled to 0° C.
- filtrationThe resulting solids were filtered
出典と根拠
- ORDレコード
- ord-15ea4c0cf2eb4d0c9ab1d8cc61e44b6f
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08841327B2
反応ノート
読み込み中…