3-(4-Nitrophenoxy)benzoic acid → 3-(4-Aminophenoxy)benzoic acid

HRID 78312

反応式

HRID 78312 の反応式
[C:1]([C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[O:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=1)([OH:3])=[O:2]>CO.[Pd]>[C:1]([C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[O:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=1)([OH:3])=[O:2]

参加物

4

反応物 1

HCID 7679193-(4-Nitrophenoxy)benzoic acid

生成物 1

HCID 230090363-(4-Aminophenoxy)benzoic acid収率 48%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A slurry of 4-(3-carboxyphenoxy)-1-nitrobenzene (5.38 g, 20.7 mmol) and 10% Pd/C (0.50 g) in MeOH (120 mL) was stirred under an H2 atmosphere (balloon) for 2 d. The resulting mixture was filtered through a pad of Celite®, then concentrated under reduced pressure to afford 4-(3-carboxyphenoxy)aniline as a brown solid (2.26 g, 48%): TLC (10% MeOH/90% CH2Cl2) Rf 0.44 (streaking).

後処理

  1. filtrationThe resulting mixture was filtered through a pad of Celite®
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-da39a2c50a7643df952190f67179ef72
出典データセット
uspto-grants-2014_09
特許番号
US08841330B2

関連ノート

読み込み中…