Oxalyl chloride → 2,2,3,3-Tetramethylcyclopropane-1-carbonyl chloride

HRID 78394

反応式

HRID 78394 の反応式
[CH3:1][C:2]1([CH3:10])[C:4]([CH3:6])([CH3:5])[CH:3]1[C:7](O)=[O:8].C(Cl)(=O)C([Cl:14])=O>C(Cl)Cl.CN(C)C=O>[CH3:1][C:2]1([CH3:10])[C:4]([CH3:6])([CH3:5])[CH:3]1[C:7]([Cl:14])=[O:8]

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 1521152,2,3,3-Tetramethylcyclopropanecarboxylic acid

生成物 1

HCID 110410022,2,3,3-Tetramethylcyclopropane-1-carbonyl chloride収率 99.6%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2,2,3,3-tetramethylcyclopropanecarboxylic acid (0.50 g, 3.5 mmol) in 18 mL of methylene chloride at 0° C. was added oxalyl chloride (0.61 mL, 7.0 mmol) and a catalytic amount of dimethylformamide (2 drops). The solution was stirred at ambient temperature for 1 hour, and then concentrated under reduced pressure to provide 0.56 g of the title compound.

後処理

  1. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-023c8dfe939e46a6aa48663fb87cc7c3
出典データセット
uspto-grants-2014_09
特許番号
US08841334B2

関連ノート

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