Thionyl Chloride → 5-Fluoro-2-methylbenzoyl chloride

HRID 78404

反応式

HRID 78404 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:14])=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([Cl:14])=[O:8]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 1821145-Fluoro-2-methylbenzoic acid

生成物 1

HCID 27373835-Fluoro-2-methylbenzoyl chloride

実験手順

A solution of 5-fluoro-2-methylbenzoic acid (380 mg, 2.47 mmol) in thionyl chloride (5 mL) was heated to reflux for 3 hours. The solution was cooled to ambient temperature and the volatile components were removed under reduced pressure. The residue was dissolved in fresh toluene (10 mL) and concentrated under reduced pressure twice and then placed under high vacuum to afford the title compound (420 mg).

後処理

  1. temperatureto reflux for 3 hours
  2. customthe volatile components were removed under reduced pressure
  3. dissolutionThe residue was dissolved in fresh toluene (10 mL)
  4. concentrationconcentrated under reduced pressure twice

出典と根拠

ORDレコード
ord-fdb9a3548b704bb7936d45fb4cc7b307
出典データセット
uspto-grants-2014_09
特許番号
US08841334B2

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