Benzene, (2-bromoethoxy)- → 4,5-Dimethyl-3-(2-phenoxy-ethyl)-3H-thiazol-2-ylideneamine hydrobromide

反応式

[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].[Br:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[BrH:9].[CH3:1][C:2]1[N:3]([CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:4](=[NH:8])[S:5][C:6]=1[CH3:7]

参加物

反応物 2

HCID 68526Benzene, (2-bromoethoxy)-

HCID 732382-Amino-4,5-dimethyl-1,3-thiazole

生成物 1

HCID 686212084,5-Dimethyl-3-(2-phenoxy-ethyl)-3H-thiazol-2-ylideneamine hydrobromide収率 50.6%

反応条件

温度: 85 °C

実験手順

A mixture of 4,5-dimethylthiazol-2-ylamine (1.0 g, 7.8 mmol) and (2-bromo-ethoxy)benzene (1.9 g, 9.4 mmol) were heated neat to 85° C. for 19 hours. The mixture was cooled to ambient temperature and the residue was crystallized from isopropanol. The solid was collected by filtration and dried under vacuum to afford 1.3 g (50%) of the title compound. MS (DCI/NH3) m/z 249 (M+H)+.

後処理

temperatureThe mixture was cooled to ambient temperature
customthe residue was crystallized from isopropanol
filtrationThe solid was collected by filtration
customdried under vacuum

出典と根拠

ORDレコード: ord-83cb530fe84542689d937de7db6523a9
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08841334B2

反応ノート

読み込み中…

参加物