2,4-Dimethoxybenzoic acid → 2,4-Dimethoxybenzoyl chloride

HRID 78466

反応式

HRID 78466 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=[O:6].O=S(Cl)[Cl:16]>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5]([Cl:16])=[O:6]

参加物

3

反応物 2

HCID 70522,4-Dimethoxybenzoic acidHCID 24386Thionyl Chloride

生成物 1

HCID 27347192,4-Dimethoxybenzoyl chloride

実験手順

A solution of 2,4-dimethoxybenzoic acid (0.25 g, 1.4 mmol) in 5 mL of SOCl2 was warmed to reflux and was allowed to stir for 2 hours. The mixture was cooled to ambient temperature and concentrated under reduced pressure. The crude material was diluted with 5 mL of toluene and concentrated under reduced pressure. This dilution with toluene and concentration was repeated two additional times to give the crude title compound which was used without additional purification or characterization.

後処理

  1. temperatureto reflux
  2. concentrationconcentrated under reduced pressure
  3. additionThe crude material was diluted with 5 mL of toluene
  4. concentrationconcentrated under reduced pressure
  5. concentrationThis dilution with toluene and concentration

出典と根拠

ORDレコード
ord-bd29039174134ba49dfadb7c87cf493a
出典データセット
uspto-grants-2014_09
特許番号
US08841334B2

関連ノート

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