関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 2-(Bromomethyl)tetrahydro-2H-pyran | HCID 141917 | — |
| 生成物 | Ammonium Hydroxide | HCID 14923 | — |
| 生成物 | 3-((tetrahydro-2H-pyran-2-yl)methyl)thiazol-2(3H)-imine | HCID 68623066 | — |
反応手順
A mixture of 2-aminothiazole (1.0 g, 10 mmol) and 2-(bromomethyl)tetrahydro-2H-pyran (1.3 mL, 10 mmol) was warmed to 85° C. and was allowed to stir for 24 hours. The mixture was cooled to ambient temperature and the crude material was purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 199 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08841334B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-9c341b032d00464bbb11e05c4adbcd36 |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
