反应详情

温度

85 °C

A mixture of 2-aminothiazole (1.0 g, 10 mmol) and 2-(bromomethyl)tetrahydro-2H-pyran (1.3 mL, 10 mmol) was warmed to 85° C. and was allowed to stir for 24 hours. The mixture was cooled to ambient temperature and the crude material was purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 199 (M+H)+.

1. temperatureThe mixture was cooled to ambient temperature
2. customthe crude material was purified via column chromatography (SiO2, 10% methanol in ethyl acetate