Thionyl Chloride → 4-Chloro-2-methoxybenzoyl chloride
反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([O:11][CH3:12])[CH:3]=1.O=S(Cl)[Cl:15]>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:15])=[O:7])=[C:4]([O:11][CH3:12])[CH:3]=1参加物
3
実験手順
A solution of the 4-chloro-2-methoxybenzoic acid (0.24 g, 1.3 mmol) in 7 mL of SOCl2 was warmed to reflux and was allowed to stir for 2 hours. The mixture was cooled to ambient temperature and concentrated under reduced pressure. The crude material was diluted with 5 mL of toluene and concentrated under reduced pressure. This dilution with toluene and concentration was repeated two additional times to give the crude title compound which was used without additional purification or characterization.
後処理
- temperatureto reflux
- concentrationconcentrated under reduced pressure
- additionThe crude material was diluted with 5 mL of toluene
- concentrationconcentrated under reduced pressure
- concentrationThis dilution with toluene and concentration
出典と根拠
- ORDレコード
- ord-6301097ee8fe426b99de7fb20b919ba6
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08841334B2
反応ノート
読み込み中…