Allyl bromide → 3-allyl-4,5-dimethylthiazol-2(3H)-imine hydrobromide
反応式
[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].[CH2:9]([Br:12])[CH:10]=[CH2:11]>C1(C)C=CC=CC=1.CCOCC>[BrH:12].[CH2:11]([N:3]1[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][C:4]1=[NH:8])[CH:10]=[CH2:9]参加物
5
反応条件
- 温度
- 85 °C
実験手順
A mixture of 4,5-dimethyl-1,3-thiazol-2-amine (1 g) and allylbromide (0.95 g) in toluene (5 mL) was heated to 85° C. for 12 hours, cooled, diluted with ether, filtered and the solvent was evaporated to afford crude product that was taken on to the next step without further characterization.
後処理
- temperaturecooled
- filtrationfiltered
- customthe solvent was evaporated
- customto afford crude product that
出典と根拠
- ORDレコード
- ord-b550bf94e1dc44afbb8ef0c33f28bdba
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08841334B2
反応ノート
読み込み中…