Allyl bromide → 3-allyl-4,5-dimethylthiazol-2(3H)-imine hydrobromide

HRID 78488

反応式

HRID 78488 の反応式
[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].[CH2:9]([Br:12])[CH:10]=[CH2:11]>C1(C)C=CC=CC=1.CCOCC>[BrH:12].[CH2:11]([N:3]1[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][C:4]1=[NH:8])[CH:10]=[CH2:9]

参加物

5

反応物 2

HCID 7841Allyl bromideHCID 732382-Amino-4,5-dimethyl-1,3-thiazole

生成物 1

HCID 686235423-allyl-4,5-dimethylthiazol-2(3H)-imine hydrobromide

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 3283Diethyl Ether溶媒

反応条件

温度
85 °C

実験手順

A mixture of 4,5-dimethyl-1,3-thiazol-2-amine (1 g) and allylbromide (0.95 g) in toluene (5 mL) was heated to 85° C. for 12 hours, cooled, diluted with ether, filtered and the solvent was evaporated to afford crude product that was taken on to the next step without further characterization.

後処理

  1. temperaturecooled
  2. filtrationfiltered
  3. customthe solvent was evaporated
  4. customto afford crude product that

出典と根拠

ORDレコード
ord-b550bf94e1dc44afbb8ef0c33f28bdba
出典データセット
uspto-grants-2014_09
特許番号
US08841334B2

関連ノート

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